Polycystic kidney disease

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Displaying 1-10 out of 22 doctors available

  1. Andrew J. Bentall

    Andrew J. Bentall

    1. Transplant Nephrologist
    2. Nephrologist
    1. Rochester, MN
    Areas of focus:

    Living donor kidney transplant, Kidney transplant, Living-donor transplant, Pancreas transplant, Transplant, Simultaneo...us pancreas-kidney transplant, Preemptive kidney transplant, Immunosuppressive drug therapy, Pre-transplant evaluation, Post-transplant long-term care, Kidney donor evaluation, Preventing infection in immunocompromised patient, Preoperative cardiac evaluation, Living kidney donation, Paired kidney donation, Post-pancreas transplant care, Living organ donation, Pre-kidney transplant evaluation, Post-kidney transplant care, Pre-pancreas transplant evaluation, Kidney failure, Polycystic kidney disease, Hydronephrosis, Kidney infection, Diabetic nephropathy, Hyperparathyroidism, Thin basement membrane disease, Metabolic acidosis, Chronic kidney disease, Renal cell carcinoma, Inherited cystic kidney disorder, Glomerulonephritis, Nephrotic syndrome, Renal parenchymal disease, Simple kidney cyst, IgA nephropathy, End-stage renal disease, Hyperoxaluria, Lupus nephritis, Secondary high blood pressure, Acute kidney injury , Minimal change disease, Renovascular disease, Immunotactoid glomerulonephritis, Hereditary nephritis, Secondary hyperparathyroidism, Post-transplant hypertension, Tertiary hyperparathyroidism, Malignant hypertension, Membranoproliferative glomerulonephritis, Interstitial nephritis, Metabolic kidney disease, Hypertensive nephropathy, Renal amyloidosis, Renal tubular acidosis, Myeloma kidney disease, Hyperphosphatemia, Primary hyperoxaluria, Renal papillary necrosis, Renovascular hypertension

  2. Fouad T. Chebib, M.D.

    Fouad T. Chebib, M.D.

    1. Jacksonville, FL
    Areas of focus:

    Kidney transplant, Pancreas transplant, Transplant, Kidney dialysis, Kidney stone, High blood pressure, Polycystic kidn...ey disease, Chronic kidney disease, Acute kidney failure, End-stage renal disease, Kidney cyst, Glomerular disease

  3. Carl H. Cramer, II

    Carl H. Cramer, II

    1. Transplant Nephrologist
    2. Pediatrician
    3. Pediatric Nephrologist
    1. Rochester, MN
    Areas of focus:

    Kidney transplant, Hemodialysis, Peritoneal dialysis, Dialysis, Kidney failure, High blood pressure, Polycystic kidney ...disease, Hydronephrosis, Kidney infection, Blood in urine, Urinary tract infection, Thin basement membrane disease, Chronic kidney disease, Glomerulonephritis, Nephrotic syndrome, High blood pressure in children, Renal artery stenosis, IgA nephropathy, End-stage renal disease, Kidney cyst, Tuberous sclerosis, Focal segmental glomerulosclerosis, Lupus nephritis, Secondary high blood pressure, Medullary sponge kidney, Nail disease, Acute kidney injury , Minimal change disease, Renovascular disease, Nephritis, Hereditary nephritis, Protein in urine, Post-transplant hypertension, Malignant hypertension, Single kidney, Childhood nephrotic syndrome, Membranoproliferative glomerulonephritis, Interstitial nephritis, Shrinking kidney, Renal tubular acidosis, Kidney injury, Multicystic kidney dysplasia, Postural proteinuria, Horseshoe kidney, Kidney angiomyolipoma, Renovascular hypertension, Glomerular disease, Congenital kidney disorder

  4. Neera K. Dahl, M.D., Ph.D.

    Neera K. Dahl, M.D., Ph.D.

    1. Internist
    2. Nephrologist
    1. Rochester, MN
    Areas of focus:

    Kidney stone, Polycystic kidney disease, Genetic disorder, Polycystic liver disease

  5. Patrick G. Dean, M.D.

    Patrick G. Dean, M.D.

    1. Transplant Surgeon
    Areas of focus:

    Kidney transplant, Pancreas transplant, Transplant, Islet cell transplant, Diabetes, Polycystic kidney disease, End-sta...ge renal disease, ADPKD

  6. Navin R. Gupta, M.D.

    Navin R. Gupta, M.D.

    1. Internist
    2. Nephrologist
    1. Rochester, MN
    Areas of focus:

    Kidney stone, High blood pressure, Polycystic kidney disease, Chronic kidney disease, Focal segmental glomerulosclerosi...s, Alport syndrome, Acute kidney injury

  7. Christian Hanna

    Christian Hanna

    1. Pediatric Nephrologist
    1. Rochester, MN
    Areas of focus:

    Kidney transplant, Hemodialysis, Peritoneal dialysis, Dialysis, Continuous renal replacement therapy, Kidney stone, Pol...ycystic kidney disease, Hydronephrosis, Hemolytic uremic syndrome, Kidney infection, Blood in urine, Urinary tract infection, Chronic kidney disease, Membranous nephropathy, Inherited cystic kidney disorder, Nephrotic syndrome, High blood pressure in children, Renal artery stenosis, IgA nephropathy, End-stage renal disease, Kidney cyst, Focal segmental glomerulosclerosis, Medullary sponge kidney, Acute kidney injury , Minimal change disease, Renovascular disease, Protein in urine, Single kidney, Childhood nephrotic syndrome, Membranoproliferative glomerulonephritis, Renal tubular acidosis, Multicystic kidney dysplasia, Postural proteinuria, Horseshoe kidney, Glomerular disease, Congenital kidney disorder

  8. Marie C. Hogan

    Marie C. Hogan

    1. Internist
    2. Nephrologist
    1. Rochester, MN
    Areas of focus:

    Polycystic kidney disease, IgA nephropathy, End-stage renal disease, Focal segmental glomerulosclerosis, Glomerular dis...ease

  9. Musab S. Hommos

    Musab S. Hommos

    1. Nephrologist
    1. Phoenix, AZ
    Areas of focus:

    High blood pressure, Polycystic kidney disease, Amyloidosis (test), Chronic kidney disease, Glomerulonephritis, Renal a...rtery stenosis, End-stage renal disease, Acute kidney injury , Renal tubular acidosis

  10. Tambi Jarmi, M.D.

    Tambi Jarmi, M.D.

    1. Transplant Nephrologist
    1. Jacksonville, FL
    Areas of focus:

    Kidney transplant, Pancreas transplant, Immunosuppressive drug therapy, Pre-transplant evaluation, Post-transplant long...-term care, Polycystic kidney disease, Diabetic nephropathy, Chronic kidney disease, Acute kidney failure, End-stage renal disease

Research

Mayo Clinic is a leader in polycystic kidney disease research. Mayo Clinic researchers discovered:

  • The main gene that causes autosomal dominant polycystic kidney disease (ADPKD)
  • The gene that causes autosomal recessive polycystic kidney disease (ARPKD)
  • A gene that causes a rare form of polycystic kidney disease associated with multiple malformations (Meckel-Gruber syndrome)
  • The polycystic kidney disease proteins polycystin 1, polycystin 2 and fibrocystin
  • The polycystic kidney and liver disease gene GANAB
  • Other genes that cause kidney cyst disease, such as DNAJB11
  • A way to use CT and MRI scans to classify polycystic kidney disease and select people for clinical trials of new therapies
  • A pioneering approach to surgery to remove diseased kidneys and transplant healthy kidneys during the same surgery

Lab-based research at Mayo Clinic has focused on:

  • Explaining how mutations in the polycystic kidney disease genes lead to cyst development
  • Preclinical studies in drug therapies for polycystic kidney disease, such as octreotide and vasopressin antagonists
  • Finding effective therapies for polycystic kidney disease and liver disease
  • Improving imaging assessments of polycystic kidney and liver disease
  • Studies of polycystic kidney disease proteins in urine particles known as exosomes
  • Testing new compounds in animal models of polycystic kidney disease
  • Studies of the hairlike structures (primary cilia) implicated in polycystic kidney disease

Mayo research has shown that a new drug (tolvaptan) can dramatically slow the development and progression of polycystic kidney disease in animal models.

Mayo researchers have also shown that another drug (octreotide) delays the development of both polycystic kidney disease and polycystic liver disease and is a potential treatment option for people with liver involvement.

These medications are now in clinical trials and tolvaptan is approved for use in some countries for polycystic kidney disease. In addition, nephrologists at Mayo Clinic are working to understand how to prevent the progression of kidney (renal) disease in patients with polycystic kidney disease.

Read more about the extensive research being done at Mayo Clinic's Robert M. and Billie Kelley Pirnie Translational Polycystic Kidney Disease (PKD) Center.

The Mayo Nephrology Collaborative Group — a consortium of nephrologists located across the United States — develops and conducts studies aimed at improving treatment of patients with renal diseases, including polycystic kidney disease.

Publications

See a list of publications by Mayo Clinic doctors on polycystic kidney disease on PubMed, a service of the National Library of Medicine.

Research Profiles

By Mayo Clinic Staff

Polycystic kidney disease care at Mayo Clinic

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Diagnosis & treatmentCare at Mayo Clinic
Jan. 25, 2024
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Living with polycystic kidney disease?

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Polycystic kidney disease

Research: It's all about patients

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Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight.